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Neuroprotective effect of naringin, a flavone glycoside in quinolinic acid-induced neurotoxicity: Possible role of PPAR-γ, Bax/Bcl-2, and caspase-3
Ist Teil von
Food and chemical toxicology, 2018-11, Vol.121, p.95-108
Ort / Verlag
England: Elsevier Ltd
Erscheinungsjahr
2018
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Huntington's disease (HD) is a complex multifactorial neurodegenerative disorder. Naringin, a flavanone glycoside exhibits potent anti-inflammatory and antiapoptotic effect.
To evaluate the effect of naringin in quinolinic acid (QA)-induced neurotoxicity in laboratory rats.
Neurotoxicity was induced in male Wistar rats by single intrastriatal injection of QA (300 nmol/4 μl saline) in striatum except non-treated. Rats were administered orally with either vehicle (distilled water (10 mL/kg) or naringin (20, 40 and 80 mg/kg) or pioglitazone (40 mg/kg, p.o.) or its combination for 28 days.
Naringin (40 and 80 mg/kg) treatment significantly (p < 0.05) attenuated QA-induced alterations in locomotor activity, rearing, grooming, neurological score, footprint analysis, grip strength and a number of slips. QA-induced altered striatal oxido-nitrosative stress (superoxide dismutase, glutathione, malondialdehyde and nitric oxide), neuroinflammatory markers (TNF-α, IL's and NF-kB mRNA) and apoptotic markers (Bax-Bcl-2, Caspase-3, and PPAR-γ mRNA) were significantly attenuated by (p < 0.05) by naringin. It also significantly increased (p < 0.05) mitochondrial complex (I-IV) activity. TTC scanning also showed that naringin treatment significantly reduced (p < 0.05) QA-induced striatal degeneration. It also significantly decreased (p < 0.05) OVA-induced elevated striatal apoptosis revealed by flow-cytometric analysis.
Naringin exerts its neuroprotective effect against QA-induced neurotoxicity via modulation of oxido-nitrosative stress, neuroinflammatory, apoptotic markers and mitochondrial complex activity. Thus, it may offer a better therapeutic alternative for the management of HD like symptoms.
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•Neurotoxicity was induced in Wistar rats by intrastriatal injection of quinolinic acid.•Naringin decreased oxido-nitrosative stress, TNF-α, IL's and NF-kB mRNA levels.•Naringin attenuated apoptosis (Bax-Bcl-2 and Caspase-3 mRNA) level.•It increased mitochondrial complex (I-IV) activity and PPARϒ mRNA expression.•Naringin exerts its neuroprotective effect against QA-induced neurotoxicity.