Details

Autor(en) / Beteiligte

• Cho, Namki
• Lee, Ki Yong
• Huh, Jungmoo
• Choi, Ji Hoon
• Yang, Heejung
• Jeong, Eun Ju
• Kim, Hong Pyo
• Sung, Sang Hyun

Titel

Cognitive-enhancing effects of Rhus verniciflua bark extract and its active flavonoids with neuroprotective and anti-inflammatory activities

Ist Teil von

• Food and chemical toxicology, 2013-08, Vol.58, p.355-361

Ort / Verlag

Oxford: Elsevier Ltd

Erscheinungsjahr

2013

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• [Display omitted] •PREF showed neuroprotective effects in vitro and cognitive enhancing effects in vivo.•Fisetin and butein attenuates LPS-induced proinflammatory mediators such as iNOS, COX-2, ERK and JNK phosphorylation.•Fisetin enhanced memory deficit induced by scopolamine by the activation of the CREB–BDNF pathway. The neuroprotective potential of flavonoids within the brain comprises anti-apoptosis of neuronal cells, anti-neuroinflammation and enhancement of cognitive function. We reported that Rhus vernciflua inhibits glutamate-induced neurotoxicity in primary cultured rat cortical cells. Here we narrowed it down to get neuroprotective fractions from the plant yielding flavonoid-rich ethyl acetate fraction (PREF). Among its active flavonoids, fisetin exhibited not only inhibitory effect against lipopolysaccharide (LPS)-induced neuroinflammation by suppressing inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 but also memory enhancing effects via reactivation of cAMP responsive element binding protein (CREB)–brain derived neurotrophic factor (BDNF) pathway in memory-impaired mice by scopolamine. Butein also showed a similar activity to fisetin even though to a lesser extent. The neuroprotection by PREF and selected flavonoids may involve maintenance of antioxidant defense mechanism including glutathione peroxidase (GSH-Px), glutathione reductase (GR) and superoxide dismutase (SOD). Conclusively, we demonstrate the R. vernciflua bark extract and its active flavonoids with potent neuroprotective and anti-inflammatory effects might be good therapeutic candidates as cognitive-enhancers.