Details

Autor(en) / Beteiligte

• Peng, Mingfang
• Wang, Chao
• Gao, Zhipeng
• Fu, Fuhua
• Li, Gaoyang
• Su, Donglin
• Huang, Lvhong
• Guo, Jiajing
• Shan, Yang

Titel

Citrus aurantium L. 'Daidai' physiological premature fruit drop relieves obesity in high-fat-diet-fed mice via modulating lipid metabolism and gut microbiota

Ist Teil von

• Food bioscience, 2024-10, Vol.61, p.104713, Article 104713

Ort / Verlag

Elsevier Ltd

Erscheinungsjahr

2024

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Obesity is a global pandemic and public health crisis over decades. Except for physical activity, dietary adjustments, pharmacotherapy and surgical interventions, prebiotics, which are believed to relieve obesity by modulating the host gut microbiota, have been a hot research area in recent years. Thus, in this study, our objective was to investigate the effects of Citrus aurantium L. 'Daidai' physiological premature fruit drop (DDPD) on obesity, and further explore whether the anti-obesity effects of DDPD relies on alterations in gut microbiota. Our findings revealed that supplementation with DDPD effectively alleviated HFD-induced obesity in mice, concomitantly reducing inflammation and oxidative stress. Moreover, DDPD reversed the imbalance of gut microbiota induced by HFD, enhancing beneficial bacteria associated with improved obesity, such as Bifidobacterium, Lachnospiraceae_NK4A136_group, Ruminococcus, and Muribaculaceae. Fecal microbiota transplantation demonstrated that DDPD-induced alterations in microbiota effectively mitigated weight gain and lipid abnormalities induced by HFD, while reshaping the microbiota composition of recipient mice to resemble that of donor mice. Notably, beneficial lipid metabolism bacterium Lachnospiraceae_NK4A136_group identified in donor mice successfully colonized in recipient mice. Additionally, transcriptomic analysis indicated that DDPD modulated lipid metabolism through regulating the expression of genes linked to Cpt1a, Agpat1, and Pnpla3. In conclusion, DDPD demonstrated promising anti-obesity properties, offering potential solutions to the global obesity epidemic. [Display omitted] •DDPD demonstrated substantial metabolic protective properties in mice fed with HFD.•DDPD induced alterations in the gut microbiota composition among mice on HFD.•DDPD exerted metabolic protection via fecal microbiota transplantation.•DDPD regulated lipid metabolism by controlling the expression of genes.•DDPD enhanced the utilization of citrus premature fruit drop as prebiotics.