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Encapsulation of quercetin in liposomes by ethanol injection and physicochemical characterization of dispersions and lyophilized vesicles
Ist Teil von
Food bioscience, 2017-09, Vol.19, p.17-25
Ort / Verlag
Elsevier Ltd
Erscheinungsjahr
2017
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Quercetin is a flavonoid with high antioxidant capacity that provides beneficial biological effects. However, the absorption rate of quercetin in the gastrointestinal tract is low but encapsulated lipid matrices, such as liposomes, can be useful to enhance its bioavailability. In this study, quercetin-loaded liposome dispersions were produced by ethanol injection and 12mM of phospholipid encapsulating 0.3% molar quercetin was suitable to evaluate physicochemical stability. The Langmuir monolayer technique indicated that it was possible to encapsulate a maximum of 0.3% molar quercetin in liposomes. Quercetin-loaded liposome dispersions presented a mean hydrodynamic diameter of 264nm and a zeta potential of −17mV, which is typical for small unilamellar vesicles produced by ethanol injection. Sucrose was used as the lyoprotectant (mass sucrose: phospholipid ratio, 4:1), and the encapsulated quercetin had not degraded after 100 days of storage. In addition, the lyophilized liposomes presented a low propensity for water adsorption and low hygroscopicity. Such behavior is considered highly suitable for stability in dried foods.