Details

Autor(en) / Beteiligte

• Fico, Giovanna
• Montejo, Laura
• De Prisco, Michele
• Gimenez-Palomo, Anna
• Bracco, Lorenzo
• Jimenez, Ester
• Olivia, Vincenzo
• Aranda, Selena
• Grande, Iria
• Murru, Andrea
• Martinez-Aran, Anabel
• Vilella, Elisabet
• Schulze, Thomas G.
• Vieta, Eduard
• Papiol, Sergi

Titel

W29. POLYGENIC RISK SCORES, AFFECTIVE TEMPERAMENTS, AND COGNITIVE OUTCOMES IN BIPOLAR DISORDER: INSIGHTS FROM A PILOT CROSS-SECTIONAL STUDY

Ist Teil von

• European neuropsychopharmacology, 2023-10, Vol.75, p.S119-S120

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Bipolar disorder (BD) is a complex psychiatric condition characterized by recurrent mood episodes and an increased risk of suicidal behavior. A higher polygenic risk score for suicide attempts (SA-PRS) has been associated with an elevated risk for psychiatric disorders, including BD [1]. Additionally, affective temperaments, play a significant role in shaping the course and outcomes of BD [2] and specific genetic polymorphisms related to suicide have been linked to cognitive impairments [3]. This pilot cross-sectional study aimed to explore the correlations between SA-PRS and BD risk and cognitive outcomes in euthymic individuals with BD and healthy controls. 78 euthymic individuals with BD and 69 healthy controls were included in the study. Affective temperaments were assessed using the TEMPS-A questionnaire and a comprehensive neuropsychological battery, which evaluated cognitive outcomes such as attention (CPT-II), working memory (arithmetic, letter number and digits subtest of WAIS III), processing speed (symbol search and key number of WAIS-III and TMT part A), verbal memory (CVLT and logical memory of WMS-III), visual memory (ROCF immediate recall), and executive functions (WCST, SCWT, TMT part B, ROCF copy and verbal fluency from COWAT test). In addition, measures of social cognition were also included (MSCEIT, AIHQ, HT and RMET). SA-PRS was computed using Bayesian regression and continuous shrinkage priors (PRS-CS) based on a recent genome-wide association study [4]. Linear regression models were used to test the association of neurocognitive relevant variables with SA-PRS. A moderation analysis was conducted to examine the moderating effect of affective temperaments on the relationship between SA-PRS and BD. The Bonferroni correction was used to account for multiple comparisons. Ancestry components, age and sex were used as covariates in the analyses. A significant association between SA-PRS and impaired immediate verbal memory (B=-99.07, SE=47.7, p=0.04) was found. Additionally, a positive significant relationship was observed between SA-PRS and BD diagnosis (B = 6.68, SE = 2.65, p = 0.01). The interaction between SA-PRS and anxious temperament showed a significant moderating effect on the relationship between SA-PRS and BD diagnosis (B = 0.59, SE = 0.25, p = 0.02). Despite the cross-sectional design, our results suggest that the impact of SA-PRS on BD risk depends on the level of anxious temperament, and SA-PRS is associated with impaired immediate verbal memory in individuals with BD. By integrating genetic and clinical information, this study provides valuable insights into sub-phenotyping individuals with BD. Future longitudinal studies are necessary to explore the dynamic nature of the possible moderating effect of affective temperaments on BD risk. Furthermore, investigating potential mediators or other relevant moderators may enhance our understanding of the observed relationships. In conclusion, this study sheds light on the intricate interplay between genetic and clinical factors in BD, specifically regarding polygenic risk scores, affective temperaments, and cognitive outcomes. These findings have implications for personalized approaches in BD management and highlight the need for further research to unravel the underlying mechanisms and identify potential mediators to inform future interventions.