Details

Autor(en) / Beteiligte

• Tomiyama, Katsunori
• Makihara, Yasuyuki
• Yamamoto, Hiroshi
• O'Sullivan, Gerard
• Nally, Rachel E
• Tighe, Orna
• Kinsella, Anthony
• Fienberg, Allen A
• Grandy, David K
• Sibley, David R
• Croke, David T
• Koshikawa, Noriaki
• Waddington, John L

Titel

Disruption of orofacial movement topographies in congenic mutants with dopamine D5 but not D4 receptor or DARPP-32 transduction 'knockout'

Ist Teil von

• European neuropsychopharmacology, 2006-08, Vol.16 (6), p.437-445

Ort / Verlag

Netherlands

Erscheinungsjahr

2006

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The role of D(1)-like [D(1), D(5)] and D(2)-like [D(2), D(3), D(4)] dopamine receptors and dopamine transduction via DARPP-32 in topographies of orofacial movement was assessed in restrained mice with congenic D(4) vs. D(5) receptor vs. DARPP-32 'knockout'. D(4) and DARPP-32 mutants evidenced no material phenotype; also, there were no alterations in topographical responsivity to either the selective D(2)-like agonist RU 24213 or the selective D(1)-like agonist SK and F 83959. In contrast, D(5) mutants evidenced an increase in spontaneous vertical jaw movements, which habituated more slowly than in wildtypes, and a decrease in horizontal jaw movements; topographical responsivity to SK and F 83959 and RU 24213 was unaltered. D(5) receptors regulate distinct topographies of vertical and horizontal jaw movement in an opposite manner. In assuming that the well-recognised role of the D(1)-like family in regulating orofacial movements involves primarily D(1) receptors, a role for their D(5) counterparts may have been overlooked.