Details

Autor(en) / Beteiligte

• Lau, Angie H.Y.
• Kan, Kelvin K.W.
• Lai, Helen W.
• Ngan, Man-P.
• Rudd, John A.
• Wai, Man-K.
• Yew, David T.W.

Titel

Action of ondansetron and CP-99,994 to modify behavior and antagonize cisplatin-induced emesis in the ferret

Ist Teil von

• European journal of pharmacology, 2005-01, Vol.506 (3), p.241-247

Ort / Verlag

Amsterdam: Elsevier B.V

Erscheinungsjahr

2005

Quelle

MEDLINE

Beschreibungen/Notizen

• The action of ondansetron (1 mg/kg, i.p.) and (+)-(2S,3S)-3-(2-methoxybenzylamino)-2-phenylpiperidine (CP-99,994; 10 mg/kg, i.p.) on spontaneous behavior and the emesis induced by cisplatin (10 mg/kg, i.p.) was studied in the ferret. Ondansetron was inactive to modify behavior, but CP-99,994 reduced spontaneous locomotor activity and lip licking by 48% ( P<0.01) and 79% ( P<0.01), respectively; CP-99,994 also abolished spontaneous burrowing activity ( P<0.05). Treatment of animals with cisplatin induced an emetic response that was abolished by both ondansetron and CP-99,994 ( P<0.01). However, cisplatin did not significantly modify other behavioral measures although animals that received CP-99,994, cisplatin, or CP-99,994 in combination with cisplatin exhibited more episodes of defecation than animals that received ondansetron ( P<0.05). The action of CP-99,994 to modify behavior in this species is discussed in relation to animal models of nausea.