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Advancement of multi-target drug discoveries and promising applications in the field of Alzheimer's disease
Ist Teil von
European journal of medicinal chemistry, 2019-05, Vol.169, p.200-223
Ort / Verlag
France: Elsevier Masson SAS
Erscheinungsjahr
2019
Link zum Volltext
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Complex diseases (e.g., Alzheimer's disease) or infectious diseases are usually caused by complicated and varied factors, including environmental and genetic factors. Multi-target (polypharmacology) drugs have been suggested and have emerged as powerful and promising alternative paradigms in modern medicinal chemistry for the development of versatile chemotherapeutic agents to solve these medical challenges. The multifunctional agents capable of modulating multiple biological targets simultaneously display great advantages of higher efficacy, improved safety profile, and simpler administration compared to single-targeted agents. Therefore, multifunctional agents would certainly open novel avenues to rationally design the next generation of more effective but less toxic therapeutic agents. Herein, the authors review the recent progress made in the discovery and design processes of selective multi-targeted agents, especially the successful application of multi-target drugs for the treatment of Alzheimer's disease.
Multi-garget drugs with a high potency and selectivity toward multiple biological targets represent a novel and efficient drug discovery paradigm. The development of multi-target drugs generally contains several main steps such as target identification and validation, hits identification, and lead component optimization. It is believed that the multifunctional drugs would be more effective for the treatment of t complex diseases such as cancer and central nervous system diseases, which may require complex therapeutic approaches. [Display omitted]
•It is shifting from the single- to multi-target drug, which is promising for combatting the complicated diseases.•Target identification is the first and critical step for multi-target drug discovery pipeline.•Rational design is the core for the development of multi-target agents involving various efficient methods.•Great progress has been made on multi-target drugs for the treatment of AD, which has been proved of clinical value.