Details

Autor(en) / Beteiligte

• Liman, Recep
• Kursunlu, Ahmed Nuri
• Ciğerci, İbrahim Hakkı
• Ozmen, Mustafa
• Acikbas, Yaser

Titel

Assessment of the cytotoxic and genotoxic potential of pillar[5]arene derivatives by Allium cepa roots and Drosophila melanogaster haemocytes

Ist Teil von

• Ecotoxicology and environmental safety, 2020-04, Vol.192, p.110328, Article 110328

Ort / Verlag

Netherlands: Elsevier Inc

Erscheinungsjahr

2020

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• In this study pillar[5]arene (P5) and a quinoline-functionalized pillar[5]arene (P5-6Q) which is used for detecting radioactive element, gas adsorption and toxic ions were synthesized. These materials were characterized by Nuclear Magnetic Resonance (NMR), Fourier Transform Infrared (FTIR), elemental analysis, melting point, Mass Spectroscopy, Scanning Electron Microscopy (SEM) and Zeta Potential. The cytotoxic and genotoxic potential of P5 and P5-6Q at distinct concentrations of 12.5, 25, 50, and 100 μg/mL were also investigated by Allium ana-telophase and comet assays on Allium cepa roots and Drosophila melanogaster haemocytes. P5 and P5-6Q showed dose dependent cytotoxic effect by decreasing mitotic index (MI) and genotoxic effect by increasing chromosomal aberrations (CAs such as disturbed anaphase-telophase, polyploidy, stickiness, chromosome laggards and bridges) and DNA damage at the exposed concentrations. These changes in P5-6Q were lower than P5. Further research is necessary to clarify the cytotoxic and genotoxic action mechanisms of P5 and P5-6Q at molecular levels. [Display omitted] •Pillar[5]arene (P5) and a quinoline-functionalized pillar[5]arene (P5-6Q) were synthesized and characterized.•The cyto-genotoxic effects of P5 and P5-6Q on Allium cepa and Drosophila melanogaster were studied.•P5 and P5-6Q decreased Mitotic indices.•P5 and P5-6Q significantly induced chromosomal aberrations and DNA damage.•Cyto-genotoxic effects increased dose dependent manner.