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Although the development of Gobi Desert in central and eastern Asia has greatly affected the regional and even the global climate, its precise origin and evolution have yet to be determined. The three preconditions for the formation of Gobi Desert are: i) a dry climate, ii) basin landforms and iii) abundant sediment production. In this study, we present a synthesis of both new and published data on the formation and evolution of Gobi Desert in central and eastern Asia. We conclude that the combined effects of mountain building, the mid-latitude westerly circulation and changes in the Asian monsoon, accompanied by global cooling, were principally responsible for the formation of modern Gobi Desert landscapes in central and eastern Asia during the late Pliocene. The arid climate in central and parts of eastern Asia probably developed in the early Cenozoic, from ~50 Ma. Related events included the collision of the Indian and Asian plates, the closure and complete retreat of the Paratethys Ocean from central Asia, and the growth of the Himalayas and the Tibetan Plateau in the Eocene through late Miocene, which blocked the water vapor supply and intensified the aridification of the Asian interior. Superimposed on the topographic changes was the process of stepwise global cooling since the early Oligocene, and in particular since the late Miocene, which controlled the formation and evolution of the Gobi Desert landscape. Global cooling weakened the Asian monsoon circulation, strengthened the westerly circulation and enhanced physical weathering processes in mountain areas, which together promoted both the aridification of the Asian interior and sediment production. These processes finally resulted in the establishment of the modern Gobi Desert landscape in the late Pliocene. We estimate that the modern Gobi Desert landscape was formed at ~2.6 Ma and was the result of the stepwise evolution of Asian topography and climate during the Cenozoic, dominated by Asian tectonic deformation and uplift, and the evolution of Asian monsoon climate and the westerly circulation, forced by global temperature change.