Details

Autor(en) / Beteiligte

• Srinivasan, Shriya S.
• Liu, Sabrina
• Hotta, Ryo
• Bhave, Sukhada
• Alshareef, Amro
• Ying, Binbin
• Selsing, George
• Kuosmanen, Johannes
• Ishida, Keiko
• Jenkins, Joshua
• Mohammed Madani, Wiam Abdalla
• Hayward, Alison
• Fabian, Niora
• Goldstein, Allan M.
• Traverso, Giovanni

Titel

Luminal electrophysiological neuroprofiling system for gastrointestinal neuromuscular diseases

Ist Teil von

• Device, 2024-07, Vol.2 (7), p.100400, Article 100400

Ort / Verlag

Elsevier Inc

Erscheinungsjahr

2024

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Gastrointestinal (GI) neuromuscular diseases can be challenging to diagnose due to inadequate profiling technologies that are unable to pinpoint underlying pathology. We introduce a luminal electrophysiological neuroprofiling system (LENS). This tool uses high-resolution electromyographic data to capture motility of the GI tract, grade neurogenic deficiencies over time, and elucidate motility patterns. Through the development of analytical metrics, we determine “neuroprofiles” for various enteric neuropathies in models of dysmotility, sphincter dysfunction, and aganglionosis. The LENS differentiates between aganglionic and ganglionic regions based on the contractile rate (p < 0.0001) and root-mean-square amplitude (p < 0.0001). In mice with hypomotility, metrics like area under the curve and peak height of the Fourier transformation of the electrophysiological signal in the frequency ranges of 0–20 and 115–135 Hz were significant differentiators, with up to 89% accuracy of classification between pathologic and normal motility. Such a platform can enable realization of specific diagnoses and quantify their severity. [Display omitted] •The LENS is a luminal electrophysiological neuroprofiling system•The LENS electrophysiologically characterizes the GI tract for disease diagnosis•Analytical metrics are generated to differentiate neuromuscular diseases•High-resolution spatial profiles identify ganglionic-aganglionic transition zones Limited tools exist to electrophysiologically characterize the gastrointestinal (GI) system for the diagnosis of GI neuromuscular diseases, due to the challenging anatomical structure of the GI tract. The luminal electrophysiological neuroprofiling system consists of an endoscopic device and series of biomarkers that can create high-resolution spatial maps of the electrical activity in the digestive tract, aiding in the diagnosis of conditions such as GI dysmotility and weakness of the muscles involved in swallowing. The system may ultimately benefit clinicians, surgeons, and patients by improving diagnostic precision and tailoring treatment plans for individuals with GI disorders. The luminal electrophysiological neuroprofiling system consists of an endoscopic device and series of biomarkers that characterize the electrical activity of the digestive tract to aid the diagnosis of gastrointestinal neuromuscular diseases. This study describes the device’s development and validation and provides example cases of neuroprofiling to detect neuropathies and aganglionosis.