Details

Autor(en) / Beteiligte

• Salgueiro-González, N.
• Turnes-Carou, I.
• Muniategui-Lorenzo, S.
• López-Mahía, P.
• Prada-Rodríguez, D.

Titel

Membrane assisted solvent extraction coupled with liquid chromatography tandem mass spectrometry applied to the analysis of alkylphenols in water samples

Ist Teil von

• Journal of Chromatography A, 2013-03, Vol.1281, p.46-53

Ort / Verlag

Amsterdam: Elsevier B.V

Erscheinungsjahr

2013

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• ► Analysis of alkylphenols in waters by MASE-LC-MS/MS. No previous works reported. ► Simplicity, fastness, selectivity and agreement with Green Chemistry principles. ► Lower MQL in compliance with Directive 2008/105/EC and proposal COM(2011)876 final. ► Fate and occurrence of APs in the seawater, surface and drinking water. ► Nonylphenol ubiquitous compound. This work describes the development and validation of a novel, simple, sensitive and environmental friendly analytical method for the determination of alkylphenols in different types of water samples. The methodology was based on a membrane assisted solvent extraction of only 15mL of water sample with 500μL of hexane in combination with liquid chromatography-electrospray ionization tandem mass spectrometry in negative mode (LC-ESI-MS/MS). Acquisition was performed in the multiple reaction monitoring (MRM) mode recording two transitions for the identification of the target compounds. Quantitation is based on the use of deuterated labelled standards as surrogate standards. The figures of merit were satisfactory in all cases: absolute recoveries were close to 50% for most investigated compounds and relative recoveries varied between 81 and 108%. Repeatability and intermediate precision were <20% for all compounds. Uncertainty assessment of measurement was estimated on the basis of an in-house validation according to EURACHEM/CITAC guide. Quantitation limits of the method (MQL) were lower than 0.04μgL−1 in all cases, which allow the achievement of the limits established by the Directive 2008/105/EC for surface and seawater samples and by the new proposal COM (2011) 876 final. The feasibility of the proposed method was demonstrated analyzing seawater, surface water and drinking water samples from different areas of A Coruña (Northwest of Spain). The analyses evidenced the presence of nonylphenol in seawater (MQL-0.13μgL−1) and surface water samples (0.12–0.19μgL−1). The highest concentration was observed in drinking water (0.25μgL−1).