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Investigation of the extraction of natural alkaloids in Karr reciprocating plate columns: Fluid dynamic study
Ist Teil von
Chemical engineering science, 2022-12, Vol.264, p.118090, Article 118090
Ort / Verlag
Elsevier Ltd
Erscheinungsjahr
2022
Link zum Volltext
Quelle
Elsevier ScienceDirect Journals Complete
Beschreibungen/Notizen
[Display omitted]
•Hydrodynamic study including liquid holdup and Sauter-mean diameter using 0.2 M Cyanex 923 diluted in xylene was investigated in a pilot-scale Karr column.•Hydrodynamic performance was modelled and regressed in an empirical correlation associated with mechanical power dissipation, phase flow rates, physical properties, and column geometry.•Hydrodynamic performance of morphine extraction using 0.2 M Cyanex 923/xylene was investigated at two Karr columns.•Model was validated from morphine extraction experiments.
Previous work found that 0.2 M Cyanex® 923 in xylene has potential to extract natural alkaloids such as morphine. In this work, pilot scale fluid dynamic tests using 0.2 M Cyanex® 923 in xylene as a dispersed phase and water as a continuous phase in a reciprocating plate Karr column were conducted at different flowrates of both phases and reciprocating frequencies. The results show that the dispersed phase liquid holdup increases with the increase of dispersed phase velocity and reciprocating frequency, and the Sauter-mean drop diameter is independent of the velocity of both phases, and it slightly reduces with increasing reciprocating frequency. The results were used to regress an empirical model. In addition, morphine extraction using the same solvents were also studied in two different Karr columns. The results were consistent with those of fluid dynamic tests, and further used to investigate the regressed model within 30 % deviation.