Details

Autor(en) / Beteiligte

• Zhang, Hao
• Li, Qingsi
• Qi, Xiaoyu
• Li, Yi
• Ma, Hongyan
• Grinholc, Mariusz
• Nakonieczna, Joanna
• Yu, Bingran
• Wang, Xing
• Zhang, Lei

Titel

Iron-blocking antibacterial therapy with cationic heme-mimetic gallium porphyrin photosensitizer for combating antibiotic resistance and enhancing photodynamic antibacterial activity

Ist Teil von

• Chemical engineering journal (Lausanne, Switzerland : 1996), 2023-01, Vol.451, p.138261, Article 138261

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2023

Quelle

ScienceDirect

Beschreibungen/Notizen

• [Display omitted] •The water solubility of gallium protoporphyrin IX was improved.•Ga-CHP can self-target bacteria and accumulate in infected wound lesions.•Ga-CHP can rapidly kill a broad spectrum of bacteria, even multidrug-resistant strains.•Unlike antibiotics, Ga-CHP cannot trigger drug resistance in terms of phenotypes and mutations.•Ga-CHP can inactivate catalase and enhance photodynamic antibacterial activity. Iron is an essential nutrient for bacterial survival and replication. Interfering with iron metabolism is a potential nondrug-resistant antibacterial strategy. Here we propose an iron-blocking antibacterial therapy (IBAT) based on cationic heme-mimetic gallium porphyrin (Ga-CHP). Cations and heme bionics facilitated the uptake of Ga-CHP by bacteria through heme metabolism and are the primary motifs for its broad-spectrum antibacterial activity. Ga-CHP can rapidly kill gram-positive and gram-negative strains, even multidrug-resistant strains. Notably, unlike antibiotics, it is hard for bacteria to evolve drug resistance in terms of phenotypes and mutations. Furthermore, Ga-CHP is also a superior photosensitizer and its antibacterial capability can be further enhanced via synergistic photodynamic therapy in vitro and in vivo due to heme-assisted catalase inactivation. This work presents an innovative antibacterial strategy for addressing antibiotic resistance crisis and enhancing photodynamic antibacterial activity.