Chinese chemical letters, 2011-09, Vol.22 (9), p.1036-1038
2011
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- Autor(en) / Beteiligte
- Titel
- Microwave-assisted synthesis of some novel fluorinated pyrazolo[3,4-d]pyrimidine derivatives containing 1,3,4-thiadiazole as potential antitumor agents
- Ist Teil von
- Chinese chemical letters, 2011-09, Vol.22 (9), p.1036-1038
- Ort / Verlag
- Elsevier B.V
- Erscheinungsjahr
- 2011
- Quelle
- Access via ScienceDirect (Elsevier)
- Beschreibungen/Notizen
- A facile microwave-assisted procedure for synthesis of novel fluorinated pyrazolo[3,4-d]pyrimidine derivatives containing 1,3,4-thiadiazole is described. This protocol presented such advantages as short reaction time, high yields, simple purification and environmentally benign procedures. Their antitumor activities were evaluated against HL-60 by an MTT assay. The preliminary results indicated that some title compounds exhibit more potent antitumor inhibitory activity than doxorubicin （DOX）.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1001-8417eISSN: 1878-5964DOI: 10.1016/j.cclet.2011.05.012Titel-ID: cdi_crossref_primary_10_1016_j_cclet_2011_05_012
- Format
- –
- Schlagworte
- 1,3,4-Thiadiazole, Antitumor activity, Microwave-assisted synthesis, Pyrazolo[3,4-d]pyrimidine, 合成过程, 吡唑, 嘧啶衍生物, 噻二唑, 微波辅助合成, 抗肿瘤活性, 抗肿瘤药物, 氟化