Carbohydrate polymers, 2021-08, Vol.266, p.118104, Article 118104
2021
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- Autor(en) / Beteiligte
- Titel
- Polypseudorotaxane and polydopamine linkage-based hyaluronic acid hydrogel network with a single syringe injection for sustained drug delivery
- Ist Teil von
- Carbohydrate polymers, 2021-08, Vol.266, p.118104, Article 118104
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2021
- Quelle
- Access via ScienceDirect (Elsevier)
- Beschreibungen/Notizen
- Polypseudorotaxane structure and polydopamine bond-based crosslinked hyaluronic acid (HA) hydrogels including donepezil-loaded microspheres were developed for subcutaneous injection. Both dopamine and polyethylene glycol (PEG) were covalently bonded to the HA polymer for catechol polymerization and inclusion complexation with alpha-cyclodextrin (α-CD), respectively. A PEG chain of HA-dopamine-PEG (HD-PEG) conjugate was threaded with α-CD to make a polypseudorotaxane structure and its pH was adjusted to 8.5 for dopamine polymerization. Poly(lactic-co-glycolic acid) (PLGA)/donepezil microsphere (PDM) was embedded into the HD-PEG network for its sustained release. The HD-PEG/α-CD/PDM 8.5 hydrogel system exhibited an immediate gelation pattern, injectability through single syringe, self-healing ability, and shear-thinning behavior. Donepezil was released from the HD-PEG/α-CD/PDM 8.5 hydrogel in a sustained pattern. Following subcutaneous injection, the weight of excised HD-PEG/α-CD/PDM 8.5 hydrogel was higher than the other groups on day 14. These findings support the clinical feasibility of the HD-PEG/α-CD/PDM 8.5 hydrogel for subcutaneous injection. •Hyaluronic acid-dopamine-polyethylene glycol (HD-PEG) was synthesized and identified.•HD-PEG was threaded with alpha-cyclodextrin (α-CD) and pH was adjusted to 8.5.•Polypseudorotaxane structure and polydopamine bond-based hydrogel was fabricated.•Donepezil-loaded microspheres were embedded in hydrogel system for sustained release.•Rheological features of injectable hydrogel were tuned for slow biodegradation.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0144-8617eISSN: 1879-1344DOI: 10.1016/j.carbpol.2021.118104Titel-ID: cdi_crossref_primary_10_1016_j_carbpol_2021_118104
- Format
- –
- Schlagworte
- Animals, Biodegradable Plastics - chemical synthesis, Biodegradable Plastics - chemistry, Biodegradable Plastics - toxicity, Crosslinked hydrogel, Cyclodextrins - chemical synthesis, Cyclodextrins - chemistry, Cyclodextrins - toxicity, Donepezil - chemistry, Drug Carriers - chemical synthesis, Drug Carriers - chemistry, Drug Carriers - toxicity, Drug Liberation, Hyaluronic Acid - analogs & derivatives, Hyaluronic Acid - toxicity, Hydrogels - chemical synthesis, Hydrogels - chemistry, Hydrogels - toxicity, Indoles - chemical synthesis, Indoles - chemistry, Indoles - toxicity, Male, Mice, Mice, Inbred ICR, Microspheres, Poloxamer - chemical synthesis, Poloxamer - chemistry, Poloxamer - toxicity, Polydopamine, Polymers - chemical synthesis, Polymers - chemistry, Polymers - toxicity, Polypseudorotaxane, Rotaxanes - chemical synthesis, Rotaxanes - chemistry, Rotaxanes - toxicity, Single syringe injection, Slow biodegradation, Sustained drug release, Viscoelastic Substances - chemical synthesis, Viscoelastic Substances - chemistry, Viscoelastic Substances - toxicity