Bioorganic & medicinal chemistry letters, 2016-01, Vol.26 (1), p.25-32
- Mougenot, Patrick
- Namane, Claudie
- Fett, Eykmar
- Goumy, Florence
- Dadji-Faïhun, Rommel
- Langot, Gwladys
- Monseau, Catherine
- Onofri, Bénédicte
- Pacquet, François
- Pascal, Cécile
- Crespin, Olivier
- Ben-Hassine, Majdi
- Ragot, Jean-Luc
- Van-Pham, Thao
- Philippo, Christophe
- Chatelain-Egger, Florence
- Péron, Philippe
- Le Bail, Jean-Christophe
- Guillot, Etienne
- Chamiot-Clerc, Philippe
- Chabanaud, Marie-Aude
- Pruniaux, Marie-Pierre
- Ménegotto, Jérôme
- Schmidt, Friedemann
- Venier, Olivier
- Viviani, Fabrice
- Nicolai, Eric
2016
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Details
- Autor(en) / Beteiligte
- Mougenot, Patrick
- Namane, Claudie
- Fett, Eykmar
- Goumy, Florence
- Dadji-Faïhun, Rommel
- Langot, Gwladys
- Monseau, Catherine
- Onofri, Bénédicte
- Pacquet, François
- Pascal, Cécile
- Crespin, Olivier
- Ben-Hassine, Majdi
- Ragot, Jean-Luc
- Van-Pham, Thao
- Philippo, Christophe
- Chatelain-Egger, Florence
- Péron, Philippe
- Le Bail, Jean-Christophe
- Guillot, Etienne
- Chamiot-Clerc, Philippe
- Chabanaud, Marie-Aude
- Pruniaux, Marie-Pierre
- Ménegotto, Jérôme
- Schmidt, Friedemann
- Venier, Olivier
- Viviani, Fabrice
- Nicolai, Eric
- Titel
- Synthesis and multiparametric evaluation of thiadiazoles and oxadiazoles as diacylglycerol acyltransferase type 1 inhibitors
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 2016-01, Vol.26 (1), p.25-32
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2016
- Quelle
- Access via ScienceDirect (Elsevier)
- Beschreibungen/Notizen
- [Display omitted] Chemical modulation of a formerly disclosed DGAT-1 inhibitor resulted in the identification of a compound with a suitable profile for preclinical development. Optimisation of solubility is discussed and a PK/PD study is presented.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/j.bmcl.2015.11.046Titel-ID: cdi_crossref_primary_10_1016_j_bmcl_2015_11_046
- Format
- –
- Schlagworte
- DGAT-1 inhibitors, Diacylglycerol acyltransferase type 1, Diacylglycerol O-Acyltransferase - antagonists & inhibitors, Diacylglycerol O-Acyltransferase - metabolism, Dose-Response Relationship, Drug, Enzyme Inhibitors - chemical synthesis, Enzyme Inhibitors - chemistry, Enzyme Inhibitors - pharmacology, Humans, Metabolic lability, Models, Molecular, Molecular Structure, Oxadiazole, Oxadiazoles - chemical synthesis, Oxadiazoles - chemistry, Oxadiazoles - pharmacology, Solubility, Structure-Activity Relationship, Thiadiazole, Thiadiazoles - chemical synthesis, Thiadiazoles - chemistry, Thiadiazoles - pharmacology