Bioorganic & medicinal chemistry letters, 2005-02, Vol.15 (4), p.1169-1172
2005
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Details
- Autor(en) / Beteiligte
- Titel
- Design, synthesis and antiinflammatory activity of novel phthalimide derivatives, structurally related to thalidomide
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 2005-02, Vol.15 (4), p.1169-1172
- Ort / Verlag
- Oxford: Elsevier Ltd
- Erscheinungsjahr
- 2005
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The synthesis and antiinflammatory activity of novel N-phenyl-phthalimide functionalized ( 4a– d, 5a, b, 6a, b) derivatives is described. As part of an ongoing effort to develop new thalidomide analogues as antiinflammatory lead-candidates, this paper describes the synthesis and antiinflammatory activity of novel N-phenyl-phthalimide functionalized derivatives ( 4a– d, 5a, b, 6a, b). The target compounds were assayed in an acute lung inflammatory model and all compounds were able to inhibit TNF-α production and subsequent neutrophil recruitment in the LPS-acute lung inflammatory model.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/j.bmcl.2004.12.012Titel-ID: cdi_crossref_primary_10_1016_j_bmcl_2004_12_012
- Format
- –
- Schlagworte
- Animals, Anti-Inflammatory Agents - chemical synthesis, Anti-Inflammatory Agents - pharmacology, Antiinflammatory activity, Biological and medical sciences, Bones, joints and connective tissue. Antiinflammatory agents, Chemotaxis - drug effects, Drug Design, Inflammation - chemically induced, Inflammation - drug therapy, Lipopolysaccharides - pharmacology, Lung Diseases - chemically induced, Lung Diseases - drug therapy, Medical sciences, Mice, Neutrophils, Neutrophils - drug effects, Pharmacology. Drug treatments, Phthalimide derivatives, Phthalimides - chemical synthesis, Phthalimides - pharmacology, Structure-Activity Relationship, Thalidomide - chemistry, Thalidomide analogues, Tumor Necrosis Factor-alpha - antagonists & inhibitors, Tumor necrosis factor-α