Details

Autor(en) / Beteiligte

• Santoni, Matteo
• Conti, Alessandro
• Burattini, Luciano
• Berardi, Rossana
• Scarpelli, Marina
• Cheng, Liang
• Lopez-Beltran, Antonio
• Cascinu, Stefano
• Montironi, Rodolfo

Titel

Neuroendocrine differentiation in prostate cancer: Novel morphological insights and future therapeutic perspectives

Ist Teil von

• Biochimica et biophysica acta, 2014-12, Vol.1846 (2), p.630-637

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2014

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• Neuroendocrine prostate cancer (NEPC) is an aggressive variant of prostate cancer that commonly arises in later stages of castration resistant prostate cancer (CRPC) The detection of NEPC has clinical implications as these patients are often treated with platinum chemotherapy rather than with androgen receptor targeted therapies. The poor molecular characterization of NEPC accounts in part for the lack of disease specific therapeutics. Several mechanisms are involved in NE differentiation, including inflammation and autophagy, and may actually represent future therapeutic targets for advanced NEPC patients. Furthermore, a growing body of evidence suggests a potential role of circulating tumor cells in the early diagnosis and treatment of NEPC. Here we summarize the recent findings on NEPC pathogenesis and we discuss the ongoing clinical trials and future perspectives for the treatment of NEPC patients. •We examine the recent findings on NEPC pathogenesis and morphologic classification.•We report the preliminary results from ongoing trials on NEPC patients.•We highlight the potential future targets in NEPC.