Biochimica et biophysica acta, 2016-05, Vol.1863 (5), p.828-837
2016
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- Autor(en) / Beteiligte
- Titel
- Role of AAA+-proteins in peroxisome biogenesis and function
- Ist Teil von
- Biochimica et biophysica acta, 2016-05, Vol.1863 (5), p.828-837
- Ort / Verlag
- Netherlands: Elsevier B.V
- Erscheinungsjahr
- 2016
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Mutations in the PEX1 gene, which encodes a protein required for peroxisome biogenesis, are the most common cause of the Zellweger spectrum diseases. The recognition that Pex1p shares a conserved ATP-binding domain with p97 and NSF led to the discovery of the extended family of AAA+-type ATPases. So far, four AAA+-type ATPases are related to peroxisome function. Pex6p functions together with Pex1p in peroxisome biogenesis, ATAD1/Msp1p plays a role in membrane protein targeting and a member of the Lon-family of proteases is associated with peroxisomal quality control. This review summarizes the current knowledge on the AAA+-proteins involved in peroxisome biogenesis and function. This article is part of a Special Issue entitled: Peroxisomes edited by Ralf Erdmann. •Four peroxisomal AAA+-proteins are known: Pex1p, Pex6p, ATAD1/Msp1p and Lon.•Pex1p/Pex6p form a hexameric complex required for peroxisomal protein import.•ATAD1/Msp1p plays a role in targeting of mitochondrial tail-anchored proteins, the function in peroxisomes is unknown.•Lon is an AAA-protease required for the quality control of peroxisomal matrix proteins.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0167-4889, 0006-3002eISSN: 1879-2596, 1878-2434DOI: 10.1016/j.bbamcr.2015.10.001Titel-ID: cdi_crossref_primary_10_1016_j_bbamcr_2015_10_001
- Format
- –
- Schlagworte
- AAA+-ATPase, Adenosine Triphosphatases - chemistry, Adenosine Triphosphatases - genetics, Adenosine Triphosphatases - metabolism, Animals, ATAD1/MSP1, ATPases Associated with Diverse Cellular Activities, Eukaryotic Cells - chemistry, Eukaryotic Cells - metabolism, Gene Expression Regulation, Humans, Lon, Membrane Proteins - chemistry, Membrane Proteins - genetics, Membrane Proteins - metabolism, Organelle Biogenesis, Peroxisome, Peroxisomes - chemistry, Peroxisomes - metabolism, Pex1p, Pex6p, Plants - chemistry, Plants - metabolism, Protein Isoforms - chemistry, Protein Isoforms - genetics, Protein Isoforms - metabolism, Protein Structure, Secondary, Protein Structure, Tertiary, Protein Transport, Saccharomyces cerevisiae - chemistry, Saccharomyces cerevisiae - metabolism, Saccharomyces cerevisiae Proteins - chemistry, Saccharomyces cerevisiae Proteins - genetics, Saccharomyces cerevisiae Proteins - metabolism, Signal Transduction