Details

Autor(en) / Beteiligte

• Stotland, Aleksandr
• Gottlieb, Roberta A.

Titel

Mitochondrial quality control: Easy come, easy go

Ist Teil von

• Biochimica et biophysica acta, 2015-10, Vol.1853 (10), p.2802-2811

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2015

Link zum Volltext

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• “Friends come and go but enemies accumulate.” — Arthur Bloch Mitochondrial networks in eukaryotic cells are maintained via regular cycles of degradation and biogenesis. These complex processes function in concert with one another to eliminate dysfunctional mitochondria in a specific and targeted manner and coordinate the biogenesis of new organelles. This review covers the two aspects of mitochondrial turnover, focusing on the main pathways and mechanisms involved. The review also summarizes the current methods and techniques for analyzing mitochondrial turnover in vivo and in vitro, from the whole animal proteome level to the level of single organelle. This article is part of a Special Issue entitled: Mitophagy. •Mitochondria come and mitochondria go, always from the one befo'•Knowledge grows, we can refine, since new tools have come on line•MitoTimer and mt-Keima give a lovely glow, and mass spectrometry with D2O•Reveal biogenesis and mitophagy as the key to organismal longevity