Details

Autor(en) / Beteiligte

• Kurakula, Kondababu
• Koenis, Duco S.
• van Tiel, Claudia M.
• de Vries, Carlie J.M.

Titel

NR4A nuclear receptors are orphans but not lonesome

Ist Teil von

• Biochimica et biophysica acta. Molecular cell research, 2014-11, Vol.1843 (11), p.2543-2555

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2014

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The NR4A subfamily of nuclear receptors consists of three mammalian members: Nur77, Nurr1, and NOR-1. The NR4A receptors are involved in essential physiological processes such as adaptive and innate immune cell differentiation, metabolism and brain function. They act as transcription factors that directly modulate gene expression, but can also form trans-repressive complexes with other transcription factors. In contrast to steroid hormone nuclear receptors such as the estrogen receptor or the glucocorticoid receptor, no ligands have been described for the NR4A receptors. This lack of known ligands might be explained by the structure of the ligand-binding domain of NR4A receptors, which shows an active conformation and a ligand-binding pocket that is filled with bulky amino acid side-chains. Other mechanisms, such as transcriptional control, post-translational modifications and protein–protein interactions therefore seem to be more important in regulating the activity of the NR4A receptors. For Nur77, over 80 interacting proteins (the interactome) have been identified so far, and roughly half of these interactions has been studied in more detail. Although the NR4As show some overlap in interacting proteins, less information is available on the interactome of Nurr1 and NOR-1. Therefore, the present review will describe the current knowledge on the interactomes of all three NR4A nuclear receptors with emphasis on Nur77. [Display omitted] •Nuclear receptors Nur77, Nurr1 and NOR-1 are ‘orphan’ receptors of the NR4A subfamily.•The NR4A receptors have no ligands.•The known protein–protein interactions of all three NR4A receptors are summarized.•Interacting proteins are transcription factors, coregulators or protein kinases.•Protein–protein interactions modulate NR4A receptor activity and function.