Details

Autor(en) / Beteiligte

• Olson, D.K.
• Fröhlich, F.
• Farese, R.V.
• Walther, T.C.

Titel

Taming the sphinx: Mechanisms of cellular sphingolipid homeostasis

Ist Teil von

• Biochimica et biophysica acta, 2016-08, Vol.1861 (8), p.784-792

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2016

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Sphingolipids are important structural membrane components of eukaryotic cells, and potent signaling molecules. As such, their levels must be maintained to optimize cellular functions in different cellular membranes. Here, we review the current knowledge of homeostatic sphingolipid regulation. We describe recent studies in Saccharomyces cerevisiae that have provided insights into how cells sense changes in sphingolipid levels in the plasma membrane and acutely regulate sphingolipid biosynthesis by altering signaling pathways. We also discuss how cellular trafficking has emerged as an important determinant of sphingolipid homeostasis. Finally, we highlight areas where work is still needed to elucidate the mechanisms of sphingolipid regulation and the physiological functions of such regulatory networks, especially in mammalian cells. This article is part of a Special Issue entitled: The cellular lipid landscape edited by Tim P. Levine and Anant K. Menon. •Sphingolipids are structural membrane components and signaling molecules.•Cells sense changes in sphingolipid levels in the plasma membrane.•Cells acutely regulate sphingolipid biosynthesis.•Membrane trafficking is an important process for sphingolipid homeostasis.