Biochimica et biophysica acta, 2006-04, Vol.1761 (4), p.474-483
2006
Details
- Autor(en) / Beteiligte
- Titel
- Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins
- Ist Teil von
- Biochimica et biophysica acta, 2006-04, Vol.1761 (4), p.474-483
- Ort / Verlag
- Netherlands: Elsevier B.V
- Erscheinungsjahr
- 2006
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Increasing evidence indicates that DHHC cysteine-rich domain-containing proteins (DHHC proteins) are protein acyltransferases. Although multiple DHHC proteins are found in eukaryotes, characterization has been examined for only a few. Here, we have cloned all the yeast and human DHHC genes and investigated their intracellular localization and tissue-specific expression. Most DHHC proteins are localized in the ER and/or Golgi, with a few localized in the plasma membrane and one in the yeast vacuole. Human DHHC mRNAs also differ in their tissue-specific expression. These results may provide clues to aid in discovering the specific function(s) of each DHHC protein.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1388-1981, 0006-3002eISSN: 1879-2618, 1878-2434DOI: 10.1016/j.bbalip.2006.03.010Titel-ID: cdi_crossref_primary_10_1016_j_bbalip_2006_03_010
- Format
- –
- Schlagworte
- Acyltransferases - classification, Acyltransferases - genetics, Acyltransferases - metabolism, Cell Line, DHHC cysteine-rich domain, Humans, Isoenzymes - classification, Isoenzymes - genetics, Isoenzymes - metabolism, Palmitoylation, Phylogeny, Protein acyltransferase, Saccharomyces cerevisiae - chemistry, Saccharomyces cerevisiae - cytology, Saccharomyces cerevisiae - metabolism, Saccharomyces cerevisiae Proteins - classification, Saccharomyces cerevisiae Proteins - genetics, Saccharomyces cerevisiae Proteins - metabolism, Subcellular Fractions - enzymology, Tissue Distribution