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Mitochondria as targets for toxicity and metabolism research using zebrafish
Ist Teil von
Biochimica et biophysica acta. General subjects, 2020-08, Vol.1864 (8), p.129634, Article 129634
Ort / Verlag
Netherlands: Elsevier B.V
Erscheinungsjahr
2020
Link zum Volltext
Quelle
ScienceDirect
Beschreibungen/Notizen
The study of mitochondrial functions in zebrafish was initiated before the 1990s and has effectively supported many of the recent scientific advances in the functional studies of mitochondria.
This work elaborates various peculiarities and general advances in the study of mitochondria using this animal model.
The inclusion of zebrafish models in scientific research was initiated with structural studies of mitochondria. Then, toxicological studies involving chemical compounds were undertaken. Currently, there is a decisive tendency to use zebrafish to understand how chemicals impair mitochondrial bioenergetics. Zebrafish modeling has been fruitful for the analysis of ion homeostasis, especially for Ca2+ transport, since zebrafish and mammals have the same set of Ca2+ transporters and mitochondrial membrane microdomains. Based on zebrafish embryo studies, our understanding of ROS generation has also led to new insights.
For the study of mitochondria, a new era was begun with the inclusion of zebrafish in bioenergetics research.
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•Zebrafish models have provided useful opportunities to investigate mitochondrial functions.•Transparent embryos and fluorescent probes have facilitated mitochondrial study.•Zebrafish models have revealed the mitochondrial etiology of many human diseases.