Biochimica et biophysica acta, 2014-08, Vol.1842 (8), p.1208-1218
2014
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Details
- Autor(en) / Beteiligte
- Titel
- Oxidative damage and the Nrf2-ARE pathway in neurodegenerative diseases
- Ist Teil von
- Biochimica et biophysica acta, 2014-08, Vol.1842 (8), p.1208-1218
- Ort / Verlag
- Netherlands: Elsevier B.V
- Erscheinungsjahr
- 2014
- Quelle
- Access via ScienceDirect (Elsevier)
- Beschreibungen/Notizen
- Oxidative damage contributes to pathogenesis in many neurodegenerative diseases. As the indicator and regulator of oxidative stress, the Nrf2-ARE pathway has been shown dynamic changes and examined for its neuroprotective role in many cases. In this review, we summarize the progress of the Nrf2-ARE pathway in combating toxicity induced from typical misfolded protein aggregates in neurodegenerative diseases, and specifically the effects on the clearance of protein aggregates. This article is part of a Special Issue entitled: Misfolded Proteins, Mitochondrial Dysfunction, and Neurodegenerative Diseases. •Oxidative damage in neurodegenerative diseases•Dynamic changes and neuroprotection of the Nrf2-ARE pathway•Effects of the Nrf2-ARE pathway on clearance of misfolded protein aggregates
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0925-4439, 0006-3002eISSN: 1879-260X, 1878-2434DOI: 10.1016/j.bbadis.2013.12.011Titel-ID: cdi_crossref_primary_10_1016_j_bbadis_2013_12_011
- Format
- –
- Schlagworte
- Animals, Antioxidant Response Elements - genetics, Humans, Misfolded proteins, Neurodegenerative diseases, Neurodegenerative Diseases - drug therapy, Neurodegenerative Diseases - genetics, Neurodegenerative Diseases - pathology, Neuroprotective Agents - pharmacology, Neuroprotective Agents - therapeutic use, NF-E2-Related Factor 2 - metabolism, Nrf2-ARE pathway, Oxidative stress, Oxidative Stress - drug effects, Oxidative Stress - genetics, Signal Transduction - drug effects, Signal Transduction - genetics