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Oxidative damage and the Nrf2-ARE pathway in neurodegenerative diseases
Ist Teil von
Biochimica et biophysica acta, 2014-08, Vol.1842 (8), p.1208-1218
Ort / Verlag
Netherlands: Elsevier B.V
Erscheinungsjahr
2014
Quelle
Access via ScienceDirect (Elsevier)
Beschreibungen/Notizen
Oxidative damage contributes to pathogenesis in many neurodegenerative diseases. As the indicator and regulator of oxidative stress, the Nrf2-ARE pathway has been shown dynamic changes and examined for its neuroprotective role in many cases. In this review, we summarize the progress of the Nrf2-ARE pathway in combating toxicity induced from typical misfolded protein aggregates in neurodegenerative diseases, and specifically the effects on the clearance of protein aggregates. This article is part of a Special Issue entitled: Misfolded Proteins, Mitochondrial Dysfunction, and Neurodegenerative Diseases.
•Oxidative damage in neurodegenerative diseases•Dynamic changes and neuroprotection of the Nrf2-ARE pathway•Effects of the Nrf2-ARE pathway on clearance of misfolded protein aggregates