Details

Autor(en) / Beteiligte

• Lu, Zhihui
• Leung, Jason CS
• Feng, Hongliang
• Zhang, Jihui
• Wing, Yun Kwok
• Kwok, Timothy CY

Titel

Circadian rest-activity rhythms and cognitive decline and impairment in older Chinese adults: a multicohort study with prospective follow-up

Ist Teil von

• Archives of gerontology and geriatrics, 2024-01, Vol.116, p.105215, Article 105215

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2024

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• •Lower relative amplitude could differentiate mild cognitive impairment from normal cognition.•Lower relative amplitude was a robust biomarker of cognitive decline and impairment.•Improving rest-activity rhythms can potentially prevent or delay Alzheimer's disease. : The associations between rest-activity rhythms and cognitive health are inconclusive. The potential changes in rest-activity rhythms in older people with mild cognitive impairment (MCI) remains unclear. This study aimed to examine the association between rest-activity rhythms and cognitive health across different outcome measures in older Chinese people. : A total of 710 community-dwelling participants (average age 81.1±5.2 years) from two cohort studies. Wrist-worn accelerometer data was used to estimate the circadian rest-activity rhythms at baseline. Cognitive function was assessed and clinical diagnosis was made at baseline and follow-up. The two-way Analysis of Co-variance was used to compare the differences in rest-activity rhythms across participants with cognitively normal, MCI and Alzheimer's disease (AD). Logistic regression models were used to investigate the association between rest-activity rhythms and incidence of cognitive decline and impairment in a 4-year prospective follow-up of cognitively normal individuals. : There was a progressive trend of lower relative amplitude and higher activity level during the least active 5 hours across participants with cognitively normal, MCI and Alzheimer's disease (AD). Among the cognitively normal participants, lower relative amplitude at baseline was associated with a greater risk of cognitive decline (per 1 SD decrease, odds ratio 1.66 [95%CI 1.13-2.45]) and increased incidence of MCI or AD (per 1 SD decrease, 1.68 [1.12-2.50]). : Lower relative amplitude could potentially serve as a robust biomarker of cognitive decline and impairment. Further studies could evaluate the potential benefits of interventions associated with rest-activity relative amplitude to prevent or delay the progression of AD.