Details

Autor(en) / Beteiligte

• Vetešník, Lukáš
• Pojezdal, Ľubomír
• Reschová, Stanislava
• Šimková, Andrea

Titel

Specific anti-SVCV antibodies in hybrids of common carp (Cyprinus carpio) and gibel carp (Carassius gibelio) reflect heterosis advantage and genetic breakdown

Ist Teil von

• Aquaculture, 2024-12, Vol.593, p.741320, Article 741320

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2024

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Spring viraemia of carp virus (SVCV) is a disease with a serious economic impact on the farming of cyprinid fish. High susceptibility to SVCV has been documented mostly in common carp (Cyprinus carpio), whilst gibel carp (Carassius gibelio) is a weakly susceptible species. Specific anti-SVCV antibodies were analyzed in pure lines of common carp and gibel carp, and various generations of F1 and post-F1 hybrids. Specifically, we focused on anti-SVCV antibodies in weakly susceptible F1 hybrids and highly infected backcross and F2 hybrids, hypothesizing that the level of anti-SVCV antibodies will reflect heterosis advantage in F1 generations and hybrid breakdown in post-F1 generations. Backcross generations with common carp exhibited the most frequently symptomatic infections, followed by pure common carp. The high capacity of susceptible common carp to produce anti-SVCV antibodies was reported, whilst gibel carp expressed almost undetectable levels of anti-SVCV antibodies. We found the very good capacity of F1 hybrids to produce anti-SVCV antibodies, suggesting heterosis advantage. In contrast, we revealed different patterns of anti-SVCV antibodies production between maternal backcrosses (having parents with the same mtDNA – here, gibel carp) and paternal backcrosses (having parents with different mtDNA, i.e., resulting from reciprocal crosses of F1 hybrids with gibel carp mtDNA and pure common carp). Whilst both maternal backcross generations and the F2 generation of hybrids tended to produce low anti-SVCV antibodies, both paternal backcross generations expressed levels of anti SVCV-antibodies similar to those of highly susceptible common carp. The low capacity to produce anti-SVCV antibodies in F2 hybrids may be interpreted as a potential consequence of genetic disruption. However, the different capacity to induce an adaptive response in paternal hybrids and maternal hybrids (with mtDNA C. gibelio) may be interpreted as potential compensation for the cyto-nuclear breakdown hypothesized for paternal hybrids when coping with viral infection. Alternatively, the genetic background of hybrid fish, i.e. a combination of the genes of highly susceptible common carp and of less susceptible gibel carp in the hybrid genome may be responsible for this pattern. •Anti-SVCV antibodies were highly expressed in common carp and weakly expressed in gibel carp.•Less susceptible F1 hybrids expressed intermediate level of antibodies suggesting hybrid heterosis.•Maternal backcrosses (C. gibelio mtDNA of both parents) and F2 hybrids expressed low level of antibodies.•Paternal backcrosses (different mtDNA of parents) expressed high level of antibodies similar to C. carpio.•The results suggest a potential compensation for the cyto-nuclear breakdown in backcrosses.