Details

Autor(en) / Beteiligte

• XX, Hamid Mohebbi
• Rohani, Hadi
• Hassan-Nia, Sadegh

Titel

The effect of 12 weeks endurance training at 2 different intensities on GLUT4 mRNA expression of soleus and gastrocnemius muscles in obese mice

Ist Teil von

• Apunts : medicina de l'esport, 2016-07, Vol.51 (191), p.93-99

Erscheinungsjahr

2016

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• The aim of this study was to investigate the expression of GLUT4 mRNA in soleus andgastrocnemius muscles in obese mice in response to endurance training. Forty male C57BL/6mice were used in this study. Eight mice (Normal Base [NB]) served as non-obese non-trainedcontrols, and 32 mice were put on a high fat diet (HFD) regimen (60% kcal fat) for 12 weeks.At week 16, the obese mice were randomized into the following treatment groups (n  p  p  < .05). It can be concluded that any disturbance in body energy balance, especially by exercise training and/or high fat diet can influence these molecular andcellular mechanisms that act to establish a stable homeostasis.< .05). In addition, GLUT4 mRNA expression of soleus and gastrocnemius muscles in LI and HI groups were significantlyhigher than OB and OC groups (= 8 each group): Obese Base [OB]; Low Intensity [LI]; High Intensity [HI]; or Obese Control [OC] groups. LIand HI trained for 5 days/week for 12 weeks on a motorized treadmill at 15 m/min on a 5% slope(for LI), and/or at 22 m/min on a 5% slope (for HI). OC mice were kept sedentarily in the cageduring the training program. GLUT4 mRNA expression was measured in gastrocnemius and soleusmuscles using a Real Time-PCR method. GLUT4 mRNA expression of soleus muscle in LI groupincreased about 2.2 fold, against about 1.6 fold for gastrocnemius (