Details

Autor(en) / Beteiligte

• Toupance, Simon
• Watfa, Ghassan
• Lakomy, Cécile
• Kearney-Schwartz, Anna
• Labat, Carlos
• Rossignol, Patrick
• Lacolley, Patrick
• Zannad, Faiez
• Benetos, Athanase

Titel

0330 : Fixed ranking of leukocyte telomere length in elderly people: results from 8 year follow-up of the ADELAHYDE cohort

Ist Teil von

• Archives of Cardiovascular Diseases Supplements, 2015-04, Vol.7 (2), p.144-144

Ort / Verlag

Elsevier France

Erscheinungsjahr

2015

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Short leukocyte telomere length (LTL) is associated with atherosclerosis in adults and diminished survival in the elderly. The prevailing view is that LTL is associated with accelerated aging since it serves as a biomarker of the cumulative burden of inflammation and oxidative stress during adult life. LTL dynamics are defined by LTL at birth, which is highly variable, and its age-dependent attrition thereafter, which is rapid during the first 20 years of life. We examined whether age-dependent LTL attrition during old age can substantially affect individuals’ LTL ranking (e.g., longer or shorter LTL) in relation to their peers and which clinical, lifestyle or genetic factors can predict it. We measured LTL by Telomeric Restriction Fragment Southern Blot (TRF) in samples donated 8 years apart on average by 76 participants of the ADELAHYDE study. Participants were men and women aged 60 to 85 years with a history of hypertension at the inclusion. We observed a mean LTL attrition of 27 bp per year which is consistent with previous data on telomere attrition in adults. No clinical, lifestyle or genetic factors seem to exert significant effect or can predict LTL attrition in elderly people. We observed a close relationship (r=0.88, figure left panel) between baseline and follow-up LTL values. Ranking individuals by quintiles revealed that 98.6% showed no rank change (59.7%) or one quintile change (38.9%) over time (figure right panel). We conclude that in elderly people, LTL is virtually anchored to a given rank with the passage of time. Accordingly, the links of LTL with atherosclerosis and longevity appear to be established early in life. It is therefore unlikely that lifestyle and its modification during old age exert a major impact on LTL ranking.