Details

Autor(en) / Beteiligte

• Wyatt, Michael D.
• Garbiras, Bonnie J.
• Lee, Moses
• Forrow, Stephen M.
• Hartley, John A.

Titel

Synthesis and DNA binding properties of a series of N to C linked and imidazole containing analogues of distamycin

Ist Teil von

• Bioorganic & medicinal chemistry letters, 1994-03, Vol.4 (6), p.801-806

Ort / Verlag

Oxford: Elsevier Ltd

Erscheinungsjahr

1994

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• A series of imidazole containing analogues linked in a head to tail fashion (N to C) and containing methylene linkers were synthesized and examined for their DNA binding properties. The triimidazole β-alanine linked compound 10a was shown to bind efficiently to GC rich sites on DNA covering six base pairs, which is in contrast to the tetraimidazole carboxamide compound 3, previously shown to be a poor DNA binder. The triimidazole β-alanine linked compound 10a was shown to bind efficiently to GC rich sites on DNA covering six base pairs which is in contrast to the tetraimidazole carboxamide compound 3, previously shown to be a poor DNA binder.