Details

Autor(en) / Beteiligte

• Clark, Donald S.
• Emery, Jared M.
• Munsell, Mark E.

Titel

Mathematical model to predict the need for neodymium:YAG capsulotomy based on posterior capsule opacification rate

Ist Teil von

• Journal of cataract and refractive surgery, 1998-12, Vol.24 (12), p.1621-1625

Ort / Verlag

New York, NY: Elsevier Inc

Erscheinungsjahr

1998

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Purpose: To evaluate a model to project the estimated time required before patients having primary phacoemulsification require neodymium:YAG (Nd:YAG) laser capsulotomy. Setting: Eleven private practices in the United States. Methods: Projections of time to capsulotomy were based on assessment of the early development of posterior capsule opacification (PCO) over Me. The PCA date were collected during a clinical study to evaluate MDX-RA, an investigational immunotoxin designed to limit epithelial cell growth, preventing postsurgical PCO. From the PCO data, the estimated time to Nd:YAG capsulotomy in a placebo,-. treated group was compared with the actual tin-e .to capsulotomy in` a' Cohort of patients from general practice who had had phacoemulsification. Resut: By 6 months, the mean Opacification Index in the MDX-RA-group was significantly lower than that in the placebo group(P < .D5) and remained significantly lower at 12 (P < .001), 18 (P < .001), and 24 (P < .016) months. The rate of POO in the MOX-RA group was approximately.6 tames lower ttrXi the in the placebo group (P < .0004). Fifty-seven percent in the Placebo group and 4% in the MDX-RA group were projected to require an Nd YAG capsulotomy within.3 years of primary cataract surgery. Projected values for the placebo group were similar to actual values observed in the population-based cohort. Conclusions: This technique could be used to predict the need for NdNAG capsulotomy using early measurements of PCO.