Details

Autor(en) / Beteiligte

• Freitas, M.L.L.
• Silva, L.P.
• Azevedo, R.B.
• Garcia, V.A.P.
• Lacava, L.M.
• Grisólia, C.K.
• Lucci, C.M.
• Morais, P.C.
• Da Silva, M.F.
• Buske, N.
• Curi, R.
• Lacava, Z.G.M.

Titel

A double-coated magnetite-based magnetic fluid evaluation by cytometry and genetic tests

Ist Teil von

• Journal of magnetism and magnetic materials, 2002-11, Vol.252 (1-3), p.396-398

Ort / Verlag

Amsterdam: Elsevier B.V

Erscheinungsjahr

2002

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• Magnetite nanoparticles pre-coated with dodecanoic acid and ethoxylated alcohol (DE) were used to obtain a physiologically stable magnetic fluid (DE–MF) sample. Three different doses of DE–MF were intraperitoneally applied to mice. Blood and peritoneum cytometry and micronucleus test were performed for 1–21 days after injection to investigate the DE–MF toxicity. Changes in cell population, peritoneum inflammation, and potential DE–MF genotoxic action were all time and dose dependent. At the lowest dose (5×10 15 particles/kg), DE–MF seems to be useful as a drug precursor with both diagnostic and therapeutic values.