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A double-coated magnetite-based magnetic fluid evaluation by cytometry and genetic tests
Ist Teil von
Journal of magnetism and magnetic materials, 2002-11, Vol.252 (1-3), p.396-398
Ort / Verlag
Amsterdam: Elsevier B.V
Erscheinungsjahr
2002
Quelle
Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
Beschreibungen/Notizen
Magnetite nanoparticles pre-coated with dodecanoic acid and ethoxylated alcohol (DE) were used to obtain a physiologically stable magnetic fluid (DE–MF) sample. Three different doses of DE–MF were intraperitoneally applied to mice. Blood and peritoneum cytometry and micronucleus test were performed for 1–21 days after injection to investigate the DE–MF toxicity. Changes in cell population, peritoneum inflammation, and potential DE–MF genotoxic action were all time and dose dependent. At the lowest dose (5×10
15 particles/kg), DE–MF seems to be useful as a drug precursor with both diagnostic and therapeutic values.