Details

Autor(en) / Beteiligte

• Kornmann, Marko
• Link, Karl H.
• Lenz, Heinz-Josef
• Pillasch, Jürgen
• Metzger, Ralf
• Butzer, Urwe
• Leder, Gerhard H.
• Weindel, Marlen
• Safi, Farouk
• Danenberg, Kathleen D.
• Beger, Hans G.
• Danenberg, Peter V.

Titel

Thymidylate synthase is a predictor for response and resistance in hepatic artery infusion chemotherapy

Ist Teil von

• Cancer letters, 1997-09, Vol.118 (1), p.29-35

Ort / Verlag

Shannon: Elsevier Ireland Ltd

Erscheinungsjahr

1997

Link zum Volltext

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• The value of intratumoral thymidylate synthase (TS) quantitation as a predictive parameter for hepatic artery infusion (HAI) chemotherapy in patients with colorectal liver metastases was investigated. Relative TS mRNA levels were determined in 29 tumor samples using a quantitative RT-PCR amplification method. The median level of expression was 3.0 × 10 −3 (no units) and varied considerably among the tumors over a range of 135-fold. Patients with low TS levels were 4.1-fold more likely to respond ( P < 0.03) compared to patients with high TS levels. Our results indicate that TS quantitation is a valuable predictive marker for tumor response to HAI therapy.