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Nutritional deficiencies associated with vitamin E deficiency in sickle cell patients; The effect of vitamin supplementation
Ist Teil von
Nutrition research (New York, N.Y.), 1990-03, Vol.10 (3), p.267-273
Ort / Verlag
Elsevier Inc
Erscheinungsjahr
1990
Link zum Volltext
Quelle
Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
Beschreibungen/Notizen
Seventy-seven patients with sickle cell disease were screened for vitamin E deficiency. Of those, 69% (53) were found to be deficient based on vitamin E levels of <12 μmol/L (5 mg/L) or vitamin E to lipid ratios <2.3 μmol/g. Riboflavin, zinc and vitamin A status were examined in the vitamin E deficient subjects. Deficiencies in these nutrients were found in 90%, 10% and 76%, respectively. Supplementation with 800 IU of vitamin E daily resulted in a progressive increase in serum vitamin E over a 6 month period. Vitamin A, zinc and riboflavin were supplemented at the RDA level for 3 months in subjects receiving either vitamin E or placebo. Serum vitamin A levels remained unchanged. Zinc levels were increased (p<0.01). Measurement of riboflavin did not demonstrate any repletion. This study demonstrates a high incidence of vitamin E, riboflavin and vitamin A deficiencies in patients with sickle cell disease and that repletion with RDA levels of riboflavin and vitamin A are insufficient to raise the status of sickle cell patients to normal levels.