Psychiatry research, 1998-01, Vol.77 (1), p.21-28
1998
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- Autor(en) / Beteiligte
- Titel
- Schizophrenic syndromes and clozapine response in treatment-resistant schizophrenia
- Ist Teil von
- Psychiatry research, 1998-01, Vol.77 (1), p.21-28
- Ort / Verlag
- Shannon: Elsevier Ireland Ltd
- Erscheinungsjahr
- 1998
- Quelle
- Access via ScienceDirect (Elsevier)
- Beschreibungen/Notizen
- Relationships between symptom profile and clozapine response were studied. Symptom scores on the Scale for the Assessment of Positive Symptoms and the Scale for the Assessment of Negative Symptoms were subjected to principal component analysis (PCA) in a group of 66 treatment-resistant schizophrenic patients, 49 of whom were treated with clozapine. Factor scores were compared among responders, non-responders and partial responders. The PCA yielded a four-factor solution, with positive symptoms, negative symptoms, cognitive disorganization and behavioral disorganization components. Cognitive and behavioral disorganization syndrome scores showed significant differences across groups. Cognitive disorganization was higher in non-responders, while behavioral disorganization was higher in partial responders. The results support the possibility of using clinical profiles to predict therapeutic response to clozapine.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0165-1781eISSN: 1872-7123DOI: 10.1016/S0165-1781(97)00129-7Titel-ID: cdi_crossref_primary_10_1016_S0165_1781_97_00129_7
- Format
- –
- Schlagworte
- Adult, Antipsychotic Agents - adverse effects, Antipsychotic Agents - therapeutic use, Biological and medical sciences, Clozapine - adverse effects, Clozapine - therapeutic use, Cognition, Dose-Response Relationship, Drug, Dyskinesia, Drug-Induced - diagnosis, Dyskinesia, Drug-Induced - drug therapy, Factor analysis, Female, Humans, Male, Medical sciences, Middle Aged, Neurologic Examination - drug effects, Neuropharmacology, Pharmacology. Drug treatments, Principal component analysis, Psychiatric rating scales, Psychiatric Status Rating Scales - statistics & numerical data, Psycholeptics: tranquillizer, neuroleptic, Psychology. Psychoanalysis. Psychiatry, Psychometrics, Psychopharmacology, Schizophrenia - drug therapy, Schizophrenic Psychology, Symptom profiles, Syndrome, Treatment Outcome