Details

Autor(en) / Beteiligte

• Clemens, JohnD
• Harris, JeffreyR
• Khan, M.R.
• Ali, M.
• Yunus, M.
• Khan, M.U.
• Svennerholm, Ann-Mari
• Sack, DavidA
• Chakraborty, J.
• Stanton, BonitaF
• Ahmed, F.
• Kay, BradfordA
• Rao, M.R.
• Holmgren, Jan

Titel

IMPACT OF B SUBUNIT KILLED WHOLE-CELL AND KILLED WHOLE-CELL-ONLY ORAL VACCINES AGAINST CHOLERA UPON TREATED DIARRHOEAL ILLNESS AND MORTALITY IN AN AREA ENDEMIC FOR CHOLERA

Ist Teil von

• The Lancet (British edition), 1988-06, Vol.331 (8599), p.1375-1379

Ort / Verlag

Elsevier Ltd

Erscheinungsjahr

1988

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• The impact of B subunit killed whole-cell (BS-WC) and killed whole-cell-only (WC) oral cholera vaccines was assessed in a randomised double-blind trial in rural Bangladesh. 62 285 children aged 2-15 years and women aged over 15 ingested three doses of one of the vaccines or placebo. During the first year of follow-up there was a 26% reduction of all visits for treatment of diarrhoea in the BS-WC group and a 22% reduction in the WC group. The reduction of all admissions for fatal or severely dehydrating diarrhoea was 48% in the BS-WC group and 33% in the WC group. Overall mortality rates were 26% lower in the BS-WC group and 23% lower in the WC group during the first year, and reductions of mortality were observed only in women vaccinated at ages over 15 years. However, no differences in cumulative mortality were evident at the end of the second year of surveillance.