Details

Autor(en) / Beteiligte

• Clemens, JohnD
• Harris, JeffreyR
• Khan, M.R
• Kay, BradfordA
• Yunus, Md
• Svennerholm, Ann-Mari
• Sack, DavidA
• Chakraborty, J
• Stanton, BonitaF
• Khan, M.U
• Atkinson, William
• Holmgren, Jan

Titel

FIELD TRIAL OF ORAL CHOLERA VACCINES IN BANGLADESH

Ist Teil von

• The Lancet (British edition), 1986-07, Vol.328 (8499), p.124-127

Ort / Verlag

London: Elsevier Ltd

Erscheinungsjahr

1986

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• The protective efficacy of oral B subunit killed whole-cell (BS-WC) and killed whole-cell (WC) cholera vaccines was assessed in 63 498 Bangladeshi children aged 2-15 years and women aged over 15 years. Each received three doses of BS-WC, WC, or placebo in a randomised, double-blinded fashion. Surveillance for cases seeking medical care up to six months after the third dose revealed 26 cases of confirmed cholera in the placebo group, 4 cases in the BS-WC group (protective efficacy 85%; p<0·0001), and 11 cases in the WC group (protective efficacy 58%; p<0·01). For each vaccine protective efficacy was consistent in different age-groups (2-10 years versus >10 years) and for different severities of cholera.