Details

Autor(en) / Beteiligte

• Bolk, J.H.
• Bussemaker, J.K.
• Elte, J.W.F.
• Haak, A.
• van der Heide, D.

Titel

THYROID-STIMULATING IMMUNOGLOBULINS DO NOT CAUSE NON-AUTONOMOUS, AUTONOMOUS, OR TOXIC MULTINODULAR GOITRES

Ist Teil von

• The Lancet (British edition), 1979-07, Vol.314 (8133), p.61-63

Ort / Verlag

Elsevier Ltd

Erscheinungsjahr

1979

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• Thyroid-stimulating immunoglobulins (TSIs) were measured by radioreceptor assay in serum from 51 patients with a multinodular goitre, divided into four groups according to thyroid function, and in 30 normal people. In 9 patients who were euthyroid and had non-autonomous thyroid function and in 6 patients who were hyperthyroid, TSI index was normal. Of 21 euthyroid patients with autonomous function only 2 had a slightly abnormal TSI index (66 in both, normal ≥68). Another series of 15 clinically euthyroid patients also had a normal TSI index. These results suggest that TSIs do not contribute to the pathogenesis of multinodular goitre, as has been suggested by others.