Details

Autor(en) / Beteiligte

• D'Auria, M.Valeria
• Paloma, Luigi Gomez
• Minale, Luigi
• Zampella, Angela
• Verbist, Jean-Francois
• Roussakis, Christos
• Debitus, Cécile
• Patissou, Josiane

Titel

Reidispongiolide A and B, two new potent cytotoxic macrolides from the new caledonian sponge Reidispongia coerulea

Ist Teil von

• Tetrahedron, 1994-04, Vol.50 (16), p.4829-4834

Ort / Verlag

Oxford: Elsevier Ltd

Erscheinungsjahr

1994

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• Two new 26-membered macrolides, reidispongiolide A ( 1) and B ( 2), have been isolated from the New Caledonian marine sponge Redispongia coerulea n.gen.n.sp. Lévi and Lévi and their structures elucidated. They are related to sphinxolides previously isolated from an unknown nudibranch and later from the sponge Neosiphonia superstes. 1 and 2 co-occurr with sphinxolide B ( 4) and D ( 3). These macrolides exhibited potent cytotoxicity against various human carcinoma cells. Two new 26-membered macrolides, reidispongiolide A and B ( 1 R=Me; 2R=H) have been isolated from the sponge Reidispongia coerulea. These macrolides exhibited potent cytotoxicity against various human carcinoma cells.