Details

Autor(en) / Beteiligte

• Miyamoto, Sayako
• Taniguchi, Takanobu
• Suzuki, Fumiko
• Takita, Manabu
• Kosaka, Nobuyuki
• Negoro, Eiju
• Okuda, Tomoyuki
• Kosaka, Hirotaka
• Murata, Satoshi
• Nakamura, Seigo
• Akagi, Yoshio
• Oshita, Masafumi
• Watanabe, Yoshinari
• Muramatsu, Ikunobu

Titel

Cloning, functional expression and tissue distribution of rabbit αla-adrenoceptor

Ist Teil von

• Life sciences (1973), 1997-05, Vol.60 (23), p.2069-2074

Ort / Verlag

Elsevier Inc

Erscheinungsjahr

1997

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• A cDNA clone, which has an open reading frame of 1398 nucleotides encoding a 466-amino-acid peptide, has been isolated from rabbit liver cDNA library. Compared with the peptide sequence, it shows high homology to αla adrenoceptors of human, bovine and rat. We expressed this clone in COS-7 and investigated the pharmacological properties, revealing similarity to those of human αla adrenoceptors. Competitive RT/PCR has detected the mRNA in variety of rabbit tissues, especially abundantly in liver, vas deferens, brain, and aorta, but not in heart.