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Efficacy of Norfloxacin in Urinary Tract Infections: Biological Effects on Vaginal and Fecal Flora
Ist Teil von
The Journal of urology, 1985-04, Vol.133 (4), p.628-630
Ort / Verlag
Hagerstown, MD: Elsevier Inc
Erscheinungsjahr
1985
Link zum Volltext
Beschreibungen/Notizen
Forty women with uncomplicated urinary tract infections were assigned randomly to receive 400mg. norfloxacin or 160mg. trimethoprim and 800mg. sulfamethoxazole twice daily for 10 days. Of the 20 patients receiving norfloxacin none had bacteriuria during or 7 days after therapy and 5 patients were reinfected within 6 weeks of therapy discontinuation. Of the 20 patients receiving trimethoprim-sulfamethoxazole therapy 1 presented with a strain resistant to trimethoprim-sulfamethoxazole and was excluded from the study. The remaining 19 patients were uninfected during and 7 days after therapy, and 6 patients were reinfected 6 weeks after therapy. All documented recurrences were caused by bacteria sensitive to the initial therapeutic agent. Anal and vaginal Enterobacteriaceae maintained their sensitivity to norfloxacin. One patient on trimethoprim-sulfamethoxazole presented with and 2 patients acquired resistant anal and vaginal Enterobacteriaceae. No adverse reactions occurred in either treatment group. Norfloxacin was as effective and safe as trimethoprim-sulfamethoxazole without emergence of resistant bacteria associated with trimethoprim-sulfamethoxazole.