Details

Autor(en) / Beteiligte

• Morikawa, Kouji
• Yamauchi, Toshie
• Aratani, Takayuki
• Oshita, Masafumi
• Kato, Hideo
• Ito, Yasuo

Titel

Evaluation of tiquizium bromide (HSR-902), a new antispasmodic agent, as an antiulcer agent

Ist Teil von

• Japanese Journal of Pharmacology, 1986, Vol.40 (suppl), p.109-109

Ort / Verlag

The Japanese Pharmacological Society

Erscheinungsjahr

1986

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• The effects of tiquizium bromide (HSR-902), a new antispasmodic agent, on the water-immersion stress ulcer, the gastric emptying, the gastric secretion and the gastric mucosal potential difference (PD) in rats were compared with those of pirenzepine dihydrochloride (Pir) and timepidium bromide (Tim). 1) HSR-902 (10 and 30 mg/kg, p.o.), Pir (10 and 30 mg/kg, p,o.) and Tim (100 mg/kg, p.o.) inhibited the water-immersion stress ulcer (23℃, 7 hr). These agents virtually did not reverse the decrease of gastric mucosal blood flow measured by the H_2 clearance method. 2) HSR-902 (10 and 30 mg/kg, p.o.) hardly influenced the gastric emptying measured by the phenol red method. Pir (30 mg/kg, p.o.), however, had a slight inhibitory effect. 3) HSR-902 (30 mg/kg) and Pir (30 mg/kg) , administered intraduodenally, inhibited the gastric secretion induced by carbachol (10 μg/kg/hr, i,v.). 4) HSR-902 (10 and 30 mg/kg, p.o.) and Pir (10 and 30 mg/kg, p.o.) inhibited the decrease of PD induced by aspirin (40 mM, 3 ml/animal, p.o.). Tim (100 mg/kg, p.o.), however, increased it. These results suggest that HSR-902 is a potent antiulcer agent without influencing the gastric emptying, and its antiulcer action may be due to antisecretory and cytoprotective activities.