Details

Autor(en) / Beteiligte

• e Silva, Maria Joselice
• Alves, Antonio José
• Do Nascimento, Silene C.

Titel

Synthesis and cytotoxic activity of N-substituted thiosemicarbazones of 3-(3,4-methylenedioxy)phenylpropanal

Ist Teil von

• Farmaco (Società chimica italiana : 1989), 1998-03, Vol.53 (3), p.241-243

Ort / Verlag

Lausanne: Elsevier SAS

Erscheinungsjahr

1998

Quelle

MEDLINE

Beschreibungen/Notizen

• Five new N-substituted thiosemicarbazones of 3-(3,4-methylenedioxy)phenylpropanal were synthesized. Safrole, a natural product obtained from sassafras oil ( Ocotea pretiosa), was oxidized to alcohol using BH 3-THF and H 2O 2, followed by oxidation to aldehyde using pyridinium dichromate (PDC) and condensation with five N-substituted derivatives of thiosemicarbazide. Tests were performed to evaluate the cytotoxic activity with continuous chain KB cells (epidermoide carcinoma of the floor of the mouth). Compounds 5 and 6 showed IC 50 values of 1.5 and 4.6 μg/ml, respectively.