Details

Autor(en) / Beteiligte

• Wallace, Douglas C.
• Shoffner, John M.
• Trounce, Ian
• Brown, Michael D.
• Ballinger, Scott W.
• Corral-Debrinski, Marisol
• Horton, Terzah
• Jun, Albert S.
• Lott, Marie T.

Titel

Mitochondrial DNA mutations in human degenerative diseases and aging

Ist Teil von

• Biochimica et biophysica acta, 1995-05, Vol.1271 (1), p.141-151

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

1995

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• A wide variety of mitochondrial DNA (mtDNA) mutations have recently been identified in degenerative diseases of the brain, heart, skeletal muscle, kidney and endocrine system. Generally, individuals inheriting these mitochondrial diseases are relatively normal in early life, develop symptoms during childhood, mid-life, or old age depending on the severity of the maternally-inherited mtDNA mutation; and then undergo a progressive decline. These novel features of mtDNA disease are proposed to be the product of the high dependence of the target organs on mitochondrial bioenergetics, and the cumulative oxidative phosphorylation (OXPHOS) defect caused by the inherited mtDNA mutation together with the age-related accumulation mtDNA mutations in post-mitotic tissues.