Details

Autor(en) / Beteiligte

• Lagunas-Solar, Manuel C.
• Carvacho, Omar F.
• Yang, Seung-Tai
• Yano, Yukio

Titel

Cyclotron production of PET radionuclides: 118Sb (3.5 min; β + 75%; EC 25%) from high-energy protons on natural Sb targets

Ist Teil von

• International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes, 1990, Vol.41 (6), p.521-529

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

1990

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• The indirect production of the 3.5 min positron emitter 118Sb (β + 75%, max. 2.70 MeV, EC 25%) from its longer-lived 118Te (6.00 d) parent was studied using 67.5, 60.0 and 42.0 MeV proton beams to irradiate natural Sb targets. The purpose of this study was to develop the basis for a 118Te (6.0 d) → 118Sb (3.5 min) generator system capable of supplying a short-lived positron emitter for the synthesis of 118Sb-labeled compounds and for the evaluation of their potential as radiopharmaceuticals for use in positron emission tomography (PET). Radionuclide yields (μCi/μAh) and total cross sections (mbarn) were measured in the 67.5–25.0 MeV energy range for all the Te radioactivities induced and detected in the Sb targets. The cumulative 118Te yield in the 67.5–25.0 MeV energy range was measured as 5.37 ± 0.54 mCi/μAh at end-of-bombardment (EOB). Maximization of yield and purities and several target options for large-scale production are also discussed. Radiochemistry and animal studies with NCA 118Sb labeled complexes were initiated at UC Berkeley and will be reported elsewhere.