Details

Autor(en) / Beteiligte

• Reig, F.
• Mestres, C.
• Antón, J.M.García
• Valencia, G.
• Alsina, M.A.

Titel

Penetration of morphine and naloxone in phosphatidylserine monolayers

Ist Teil von

• International journal of pharmaceutics, 1988-06, Vol.44 (1), p.269-272

Ort / Verlag

Amsterdam: Elsevier B.V

Erscheinungsjahr

1988

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• The interaction between morphine or naloxone and phosphatidylserine (PS), has been studied using monomolecular layers as membrane model. The penetration kinetics of both molecules measured at different monolayer pressures and for increasing opiate concentrations has been determined. The results show that penetration of morphine presents a maximum at 15 mN · m −1 of initial PS pressure whereas that of naloxone has a maximum at 10 mN · m −1.