Details

Autor(en) / Beteiligte

• Fleitman, J.
• Perrin, J.H.

Titel

The binding of benoxaprofen to human serum albumin. Classification of the primary binding site

Ist Teil von

• International journal of pharmaceutics, 1982-01, Vol.11 (3), p.215-225

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

1982

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• Benoxaprofen, a new non-steroidal anti-inflammatory drug, is shown by dialysis and microcalorimetry to have a very high affinity for human serum albumin. At low drug-to-protein ratios it does not share the same binding site as warfarin on albumin but does share a site with flufenamic acid and clofibrate. Data are presented which show that spectroscopic evidence can be unreliable in assigning binding sites and predicting drug interactions.