Details

Autor(en) / Beteiligte

• Noriyuki, Muranushi
• Mariko, Kinugawa
• Yasuko, Nakajima
• Shozo, Muranishi
• Hitoshi, Sezaki

Titel

Mechanism for the inducement of the intestinal absorption of poorly absorbed drugs by mixed micelles I. Effects of various lipid—bile salt mixed micelles on the intestinal absorption of streptomycin in rat

Ist Teil von

• International journal of pharmaceutics, 1980, Vol.4 (4), p.271-279

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

1980

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• The effects of various lipid—bile salt mixed micelles on the intestinal absorption of streptomycin were investigated using in situ closed-loop method in the rat. Lipids used were fatty acids, glycerides, oleyl alcohol and methyl oleate. Mixed micelles composed of monoolein or unsaturated fatty acids markedly enhanced the absorption of streptomycin in the large intestine. On the other hand, saturated fatty acids caused a small enhancement of the absorption. Triolein, diolein, oleyl alcohol and methyl oleate had no enhancing effect on the absorption. To clarify the difference in the enhancing effects of monoolein, unsaturated fatty acids and saturated fatty acids, the interaction of the drug with mixed micelles, the absorbability of lipids and the alteration of the mucosal membrane permeability induced by mixed micelles were investigated. The alteration of the mucosal membrane permeability was examined by an exsorption experiment. The difference in the enhancing effects was not attributed to the interaction or the absorbability of lipids, but a close correlation was found between the enhancing effects and the alteration of the mucosal membrane permeability. Monoolein or unsaturated fatty acids mixed micelles markedly increased the mucosal membrane permeability, while bile salt or saturated fatty acid mixed micelles caused small or no alteration of the permeability. The enhancement of the intestinal absorption by mixed micelles was mostly due to the alteration of the mucosal membrane permeability.