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Research on antibacterial and antifungal agents. XI. Synthesis and antimicrobial activity of N-heteroaryl benzylamines and their Schiff bases
Ist Teil von
European journal of medicinal chemistry, 1995, Vol.30 (2), p.123-132
Ort / Verlag
Oxford: Elsevier Masson SAS
Erscheinungsjahr
1995
Link zum Volltext
Quelle
Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
Beschreibungen/Notizen
The synthesis and antimicrobial activity of new
N-heteroaryl benzylamines and their Schiff bases are reported. Antifungal data were compared with those obtained with miconazole, ketoconazole, enilconazole and imazalil sulfate, which showed that some of the tested compounds possessed moderate activity against strains of
Candida albicans,
Candida sp and good activity against isolates of plant pathogenic fungi. In contrast the synthesized compounds showed poor antibacterial activity, except for
3j which exhibited a better activity than nalidixic acid used as positive control. The results obtained are discussed on the basis of structure-activity relationships.